Why the study?
Does local application of adenosine, ATP, or their analogues modulate intrinsic cardiac neuronal activity in anesthetized dogs?
Does local application of adenosine, ATP, or their analogues modulate intrinsic cardiac neuronal activity in anesthetized dogs?
Exogenous purines modulate intrinsic cardiac neuronal activity, indicating that purine-sensitive intrinsic cardiac neurons are involved in cardiac regulation.
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Findings in anesthetized dogs warrant no clinical application yet; leaves open whether purines modulate human intrinsic cardiac neuronal activity.
Huang et al. (1993) studied this question.
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