Why the study?
Do neuronal ion channel modifying agents influence the electrical activity of intrinsic cardiac neurons in situ in anesthetized dogs?
Population
Anesthetized dogs (canine model)
Comparison
Continuous local arterial infusion of neuronal… vs Control (activity before infusion)
Design
Preclinical
Authors
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Should not alter clinical management; confirms in vitro data in an in situ canine model but leaves human translation open.
Do neuronal ion channel modifying agents influence the electrical activity of intrinsic cardiac neurons in situ in anesthetized dogs?
Specific ion channels (INa, ICaL, IKv, and IKCa) are involved in the capacity of intrinsic cardiac neurons to generate action potentials in situ, consistent with previous in vitro findings.
Thompson et al. (2000) studied this question.
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