Population
Closed chest canine model (pentobarbital anaesthetized dogs)
Design
Preclinical
Follow-up
up to 120 seconds
Authors
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ATP vagal reflex effects require human validation before any clinical consideration; leaves open differential adenosine mechanisms for translational research.
This preclinical study demonstrates that the electrophysiologic effects of ATP on the SA and AV nodes are largely mediated by a vagal reflex, unlike adenosine.
Pelleg et al. (1985) studied this question.
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