Why the study?
Does ouabain affect potassium exchange and contraction in isolated human and rabbit myocardium?
Population
Strips of human atrial and ventricular muscle, right ventricular rabbit papillary muscles, and rabbit…
Comparison
Ouabain exposure for 30 minutes at various… vs Lower concentrations of ouabain (<10(-7) mol/l)
Design
Preclinical
Follow-up
30 minutes
Authors
Loading...
High concentrations needed for effects in isolated myocardium leave open whether sodium pump inhibition occurs at therapeutic ouabain doses in patients.
Does ouabain affect potassium exchange and contraction in isolated human and rabbit myocardium?
In isolated human and rabbit myocardium, ouabain's positive inotropic effect is inseparable from potassium loss (sodium pump inhibition), occurring at concentrations ≥10(-7) mol/l.
Poole-Wilson et al. (1979) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: