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A major controversy surrounding juvenile papilloma is whether or not these lesions ever spontaneously undergo malignant change. One view contends that malignant change never takes place unless the lesion is irradiated. Presented is a 22-year-old man who suddenly develops features of extensive malignant invasion of his neck and mediastinum but has no history of irradiation.
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Robert J. Keim (1980) studied this question.
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