January 1, 2000Cardiology

Reduced Heart Rate Variability in Ischemic Heart Disease Is Only Partially Caused by Ischemia

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Why the study?

Does complete revascularization by means of PTCA improve heart rate variability in patients with uncomplicated angina?

Population

89 subjects total: 48 patients with angina and 41 age-matched healthy control subjects.

Comparison

Complete revascularization by means of… vs Age-matched healthy control subjects and…

Design

Cohort

Follow-up

6 months

Authors

BWBertil WennerblomInterventional / Structural Cardiology LLLeon LurjeSahlgrenska University Hospital JSJens SolemSahlgrenska University Hospital

Discussion

Member takes

Implication

Partial vagal recovery after PTCA in angina suggests ischemia is one but not sole mechanism of reduced HRV; hypothesis-generating, should not yet change practice.

Structured PICO

Does complete revascularization by means of PTCA improve heart rate variability in patients with uncomplicated angina?

Population

89 subjects total: 48 patients with angina (no prior acute myocardial infarction, no other disease, drug-free) and 41 age-matched healthy control subjects.

Intervention

Complete revascularization by means of percutaneous transluminal coronary angioplasty (PTCA).

Comparator

Age-matched healthy control subjects (for baseline comparison) and pre-PTCA baseline (for longitudinal comparison).

Outcome

Heart rate variability (HRV) parameters (mean RR interval, SD, rMSSD, pNN50, total power, low- and high-frequency peak, SDNN, SDANN, LF/HF) measured by 24-hour Holter recordings and during controlled respiration/cold pressure test at 1 and 6 months.surrogate

Complete revascularization via PTCA in patients with uncomplicated angina leads to a partial normalization of vagal modulation, suggesting ischemia is only one mechanism of reduced HRV in this population.

Cite This Study

Wennerblom et al. (2000) studied this question.

synapsesocial.com/papers/6a912ca2ce47fdb2afb3920a https://doi.org/10.1159/000047309

Topics

Women and heart disease

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Implication

Partial vagal recovery after PTCA in angina suggests ischemia is one but not sole mechanism of reduced HRV; hypothesis-generating, should not yet change practice.

Reduced Heart Rate Variability in Ischemic Heart Disease Is Only Partially Caused by Ischemia

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Reduced Heart Rate Variability in Ischemic Heart Disease Is Only Partially Caused by Ischemia

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider