Population
Single cultured chicken embryonic aortic and gizzard smooth muscle cells
Comparison
Forced expression of essential myosin light… vs Forced expression of the endogenous MLC isoform
Design
Preclinical
Authors
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MLC17 isoforms modulate smooth muscle force kinetics in animal models; leaves open in vivo roles or therapeutic targeting in humans.
The essential myosin light chain isoform MLC(17) is a molecular determinant of the contractile properties of smooth muscle, directly affecting the rate of force activation.
Huang et al. (1999) studied this question.
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