Why the study?
Does the rate of Ca2+-induced Ca2+ release correlate with clinical classification in patients with suspected malignant hyperthermia?
Does the rate of Ca2+-induced Ca2+ release correlate with clinical classification in patients with suspected malignant hyperthermia?
Accelerated CICR is found in only a subset of suspected malignant hyperthermia cases, suggesting alternative mechanisms may exist for some patients.
Rates of Ca2+-induced Ca2+ release (CICR) using the skinned fiber method were measured in the muscle fibers biopsied from 75 clinically suspected malignant hyperthermia (MH) patients. Their results were highly correlated to clinical classification (fulminant or abortive). Only 40% of clinically suspected MH (87% of fulminant and 18% of abortive MH) showed accelerated CICR, while others were normal in Ca2+ release rates. This suggests that some of the MH cases might be caused by a different mechanism other than the mechanism responded to the accelerated rate of CICR. This gives rise to the further discussion related to the dantrolene efficacy on the MH treatment since dantrolene works specifically on the CICR channel.
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Matsui et al. (1994) studied this question.
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