Why the study?
The effect of the mammalian orthoreovirus double-stranded RNA-binding protein σ3 during viral infection remains largely unknown.
Population
Cultured cells and mice infected with reovirus
Comparison
Recombinant viruses expressing σ3 mutants K287T and R296T vs WT virus
Design
Preclinical experimental study
Authors
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σ3 dsRNA-binding mutants decouple PKR inhibition from replication defects and myocarditis in mice; leaves open σ3 as a target in viral cardiac injury.
The reovirus σ3 protein functions to suppress PKR activation and stress granule formation, which correlates with viral replication and the development of myocarditis in mice.
Guo et al. (2021) studied this question.
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