Key result
Reovirus strain T1L, but not T3D, expresses a protein variant (μ2) that localizes to nuclear speckles, targets the mRNA splicing factor SRSF2, and alters host cell RNA splicing to benefit viral replication.
Population
Host cells infected with mammalian reovirus strains T1L or T3D
Comparison
Reovirus strain T1L infection vs Reovirus strain T3D infection
Design
Preclinical
Authors
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Strain-specific μ2 nuclear effects warrant model caution; leaves open SRSF2 contribution to interferon repression.
The reovirus T1L μ2 protein antagonizes the host splicing factor SRSF2 to alter cell mRNA splicing, creating favorable conditions for viral replication.
Rivera-Serrano et al. (2017) studied Reovirus infection. Reovirus strain T1L infection vs. Reovirus strain T3D infection was evaluated on Alteration of cell RNA splicing and interaction with SRSF2. Reovirus strain T1L, but not T3D, expresses a protein variant (μ2) that localizes to nuclear speckles, targets the mRNA splicing factor SRSF2, and alters host cell RNA splicing to benefit viral replication.
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