Second-Generation Tests for Hepatitis C Virus

Letters1 November 1991Second-Generation Tests for Hepatitis C VirusManuel Rodríguez, MD, Luis Rodrigo, PhD, Francisco Tévar, MDManuel Rodríguez, MDSearch for more papers by this author, Luis Rodrigo, PhDSearch for more papers by this author, Francisco Tévar, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-115-9-747 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: The first-generation enzyme-linked immunosorbent assay (ELISA) for hepatitis C virus (HCV), which detects antibodies against c-100 antigen, is positive in about 70% (1) and 75% (2) of patients with acute and chronic non-A, non-B hepatitis, respectively. Furthermore, using this assay, antibody detection in patients with acute non-A, non-B hepatitis is considerably delayed (3).Recently, a second-generation ELISA was developed; it incorporates one antigen from the nonstructural NS3 and NS4 regions (c200) and a HCV-core-associated antigen (c22-3). We have evaluated this assay (Ortho Diagnostic Systems, Raritan, New Jersey) in patients with acute and chronic non-A, non-B hepatitis who...References1. AlterHadlerJudsonMaresAlexanderHu MSFAWP. Risk factors for acute non-A, non-B hepatitis in the United States and association with hepatitis C virus infection. JAMA. 1990;264:2231-5. CrossrefMedlineGoogle Scholar2. KuoChooAlterGitnickRedekerPurcell GQHGAR. An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis. Science. 1989;244:362-4. CrossrefMedlineGoogle Scholar3. WangWangLinSheuSungChen JTJJJD. Hepatitis C virus in a prospective study of posttransfusion non-A, non-B hepatitis in Taiwan. J Med Virol. 1990;32:83-6. CrossrefMedlineGoogle Scholar4. MarcellinMartinot-PeignouxBoyerPouteauAumontErlinger PMNMPS. Second generation (RIBA) test in diagnosis of chronic hepatitis C. Lancet. 1991;337:551-2. CrossrefMedlineGoogle Scholar1. AlbertiChemelloCavallettoTaggerDal CantonBizzaro ALDAAN. Antibody to hepatitis C virus and liver disease in volunteer blood donors. Ann Intern Med. 1991;114:1010-2. LinkGoogle Scholar2. JadoulCornuvan Ypersele de Strihou MCC. Non-A, non-B hepatitis in dialysis patients: diagnosis, prevention and treatment. In: Andreucci VE, Fine LG, eds. International Yearbook of Nephrology. London: Springer-Verlag; [In press]. Google Scholar3. CraxiFiorentinoDi MarcoMagrinFabrianoPagliaro AGVSCL. Second generation tests in diagnosis of chronic hepatitis C. Lancet. 1991;337:1354. CrossrefMedlineGoogle Scholar4. GilliMorettiSoffrittiMenini PMDC. Anti-HCV positive patients in dialysis units? Lancet. 1990;336:243-4. CrossrefGoogle Scholar5. EbelingNaukkarinenMyllyläLeikola FRGJ. Second-generation RIBA to confirm diagnosis of HCV infection. Lancet. 1991;337:912-3. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Blood Transfusion Center 33006 Oviedo Spain PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEpidemiological, clinical and biological characteristics of acute non-A, non-B hepatitis with and without hepatitis C virus infectionPeptide based enzyme immunoassays for detecting hepatitis C antibodies in sera of people at high risk.Outcome of HCV infection after renal transplantationIncidence and risk factors for hepatitis C seroconversion in hemodialysis: A prospective studyHepatitis C virus infection in patients with acute hepatitis BViral Infections in Dialysis Patients Part B: Dialysis Associated Hepatitis 1 November 1991Volume 115, Issue 9Page: 747-748KeywordsAntibodiesAntigensChronic hepatitisEnzyme linked immunosorbent assayHepatitisHepatitis C virus Issue Published: 1 November 1991 PDF downloadLoading ...