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September 1, 1990Nucleosides and Nucleotides

Synthesis and Antiviral Activity of the 3-Deaza Analogue of 9-((1, 3-Dihydroxy-2-propoxy)Methyl)Guanine

D. P. C. MCGEE John C. Martin Donald F. Smee Julien P. H. Verheyden

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Abstract

The synthesis of 3-deaza-DHPG 2 and its positional isomer 10 via the acid catalysed fusion of imidazole 3 and acetoxymethylglycerol 4 is described. Analogue 2 has activity against herpes simplex viruses and cytomegalovirus.

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MCGEE et al. (1990) studied this question.

synapsesocial.com/papers/6a912f69a84e863524465905 https://doi.org/10.1080/15257779008043147

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