Why the study?
Does angiotensin inhibit renin production and release in an in vitro renal cell suspension system?
Does angiotensin inhibit renin production and release in an in vitro renal cell suspension system?
Angiotensin directly inhibits renin production and release in renal cells in vitro, suggesting a direct chemical feedback mechanism.
Does not inform clinical renin-angiotensin management; leaves open in vivo relevance of direct feedback.
A preparation of a renal cell suspension system suitable for renin studies was utilized to investigate the in vitro effects of angiotensin which has previously been shown to influence renin production in vivo. The addition of angiotensin to the incubated samples caused a significant inhibition of renin production and release. It is suggested that the renin-inhibitory effect of angiotensin in the intact animal might be due, at least in part, to a direct chemical action on the renal cells.
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Andrew M. Michelakis (1971) studied this question.
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