Key result
Isolated rat glomeruli can generate angiotensin II independent of neural, hormonal, or vascular control, with production estimated at 3.77 pg/mg protein/15 min.
Population
Isolated glomeruli from adult Wistar-Kyoto rats
Comparison
Incubation with angiotensinogen-rich serum and… vs Incubation in Krebs buffer without additions or…
Design
Preclinical
Follow-up
15 minutes (incubation time)
Authors
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Supports local glomerular RAS in rats; leaves open relevance to human kidney disease.
The study demonstrates that rat glomeruli possess an independent, local renin-angiotensin system capable of generating angiotensin II.
Atiyeh et al. (1995) studied this question. In vitro incubation and perturbations (e.g., angiotensinogen-rich serum, enalaprilat) was evaluated on Production of angiotensin II (ANG II). Isolated rat glomeruli can generate angiotensin II independent of neural, hormonal, or vascular control, with production estimated at 3.77 pg/mg protein/15 min.
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