Syntheses and1H-NMR Studies on Mucin-Type Sugars Chirally Deuterated at the C-6 Position

1-O-Methyl analogs of mucin oligosaccharide components, D-GalNAc (1a and 1b). β-D-Galp-(1-3)-D-GalNAc (2) and β-D-Galp(1-3)-[β-D-GlcNAc-(1-6)]-D-GalNAc (3) in which the H-6proS proton was selectively replaced by a deuterium, were synthesized to study the solution conformations about the C5-C6 fragments by 1H-NMR spectroscopy. The study revealed the preference of the gt-conformer for these sugars.