September 1, 1987Neurology

Hereditary motor and sensory neuropathy, X‐linked

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Population

38 individuals from a family with X-linked sensorimotor peripheral neuropathy, including 13 affected males…

Design

Case_series

Authors

MRMarvin P. RozearDurham Technical Community College MPM. A. Pericak‐VanceUniversity of Miami KFK. H. FischbeckNational Institutes of Health

Discussion

Member takes

Implication

Variable severity by sex warrants cautious genetic counseling; leaves open validation of the DXYS1-p58-1 locus in independent cohorts.

Structured PICO

Population

38 individuals from a family with X-linked sensorimotor peripheral neuropathy, including 13 affected males and 25 obligate or probable heterozygous females

Intervention

Clinical evaluation and DNA probe analysis

Outcome

Clinical involvement severity and genetic localizationsurrogate

This study confirms the existence of X-linked sensorimotor peripheral neuropathy and maps its gene to the DXYS1-p58-1 region of the X-chromosome.

Cite This Study

Rozear et al. (1987) studied this question.

synapsesocial.com/papers/6a9131c15f49dca04d2e4f78 https://doi.org/10.1212/wnl.37.9.1460

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Hereditary motor and sensory neuropathy, X‐linked

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Hereditary motor and sensory neuropathy, X‐linked

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider