Why the study?
In-depth study of cardiac heterogeneity and cell-to-cell interactions is needed to reveal the pathogenesis of diabetic myocardial fibrosis and identify potential therapeutic targets.
Does specific inhibition of Pdgfra axis or Itgb1 knockdown improve myocardial fibrosis in mice with HFD/STZ-induced diabetes?
Population
Mice with high-fat-diet/streptozotocin-induced diabetes
Design
Single-cell RNA-sequencing preclinical study
Authors
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Single-cell drivers of diabetic myocardial fibrosis in mice are hypothesis-generating; leaves open human translation and therapeutic targeting.
Does specific inhibition of Pdgfra axis or Itgb1 knockdown improve myocardial fibrosis in mice with HFD/STZ-induced diabetes?
Single-cell RNA sequencing identifies the Pdgfra axis and Itgb1 as key intercellular communication drivers and potential therapeutic targets for diabetic myocardial fibrosis.
Li et al. (2022) studied this question.
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