Key result
Electron microscopy combined with stereology provided precise and sensitive collagen quantification, revealing significant increases between cardiomyocytes in a porcine heart failure model.
Why the study?
Which histological method is most accurate and sensitive for quantifying cardiac collagen in a porcine model of heart failure with preserved ejection fraction?
Which histological method is most accurate and sensitive for quantifying cardiac collagen in a porcine model of heart failure with preserved ejection fraction?
Electron microscopy-stereology and automated image analysis are superior to semiautomated thresholding for accurate quantification of subtle cardiac fibrosis.
No takes yet. Share an insight, caveat, or question.
Electron microscopy-stereology may refine fibrosis quantification in animal HF models; leaves open human HFpEF validation.
Schipke et al. (2017) studied early stage heart failure with preserved ejection fraction. Electron microscopy-stereology and light microscopy-stereology vs. Semiautomated threshold analyses was evaluated on Estimated collagen content. Electron microscopy combined with stereology provided precise and sensitive collagen quantification, revealing significant increases between cardiomyocytes in a porcine heart failure model.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: