Synthesis of Chiral 1,1′‐Iminodicarboxylic Acid Derivatives from α‐Amino Acids, Aldehydes, Isocyanides, and Alcohols by the Diastereoselective Five‐Center–Four‐Component Reaction

Not only yields of up to 98% but also diastereomeric excesses of up to 84% are the advantages of this effective and versatile multicomponent reaction for the synthesis of iminodicarboxylic acid derivatives in a one-pot reaction [Eq. (a)].