We report on a 17-year-old Japanese boy with Möbius sequence, peripheral neuropathy, and hypogonadotropic hypogonadism, the fourth such case known to us. The association of peripheral neuropathy and hypogonadotropic hypogonadism in Möbius sequence seems to be more than coincidence. Pulsatile gonadotropin-releasing hormone administration for 3 months showed the effectiveness of this treatment for this patient.
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Kawai et al. (1990) studied this question.
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