Natriuretic Peptide Signaling via Guanylyl Cyclase (GC)-A: An Endogenous Protective Mechanism of the Heart

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Population

Mice deficient for GC-A and humans with functional mutations in the GC-A gene promoter

Design

Review

Authors

Discussion

Supports GC-A pathway investigation in hypertrophy; hypothesis-generating and should not yet change practice.

Population

Mice deficient for GC-A and humans with functional mutations in the GC-A gene promoter

Intervention

Natriuretic peptide signaling via Guanylyl Cyclase (GC)-A

Outcome

Cardiac hypertrophy, fibrosis, and hypertension

The endogenous ANP/BNP-GC-A signaling pathway plays a crucial cardioprotective role against pathological hypertrophy and remodeling.

Kishimoto et al. (2009) studied this question.

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