Long-term follow-up of normal volunteers exposed to Metrazol suggests that marked subjective responses, rather than EEG changes or seizures, correlate with poorer subsequent life experiences and physical health.
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Marked subjective responses to Metrazol may signal later health risks; hypothesis-generating for subjective experience as a prognostic marker in observational cohorts.
A follow-up questionnaire in regard to interval life experiences was returned by 26 of 39 subjects who had participated in a study on Metrazol tolerance 10 years earlier. It was found that the subjects who had shown spike wave activity in the electroencephalogram—or generalized seizures—had done well in all respects during the interval. Their children have, so far, not had febrile or afebrile convulsive seizures. The subjects who had experienced a marked subjective response to the drug had not done as well. They had suffered more physical illnesses in the interval and expressed general dissatisfaction with their life achievements. The case of 1 subject who had died of suicide is presented briefly to highlight the interactions between physiological and psychological mechanisms.
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Rodin et al. (1970) studied this question.
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