Why the study?
Does single dose inhaled tiotropium alter heart rate variability in healthy volunteers?
Does single dose inhaled tiotropium alter heart rate variability in healthy volunteers?
A single dose of inhaled tiotropium does not significantly alter cardiac autonomic modulation as measured by heart rate variability in healthy volunteers.
Single-dose tiotropium leaves HRV unaltered in healthy volunteers; confirms no acute autonomic effects and leaves patient data open.
Aim: Anticholinergic drugs may alter cardiac autonomic modulation. The aim of this study was to investigate the effects of inhaled tiotropium on heart rate variability (HRV). Methods: A randomized, double-blind, crossover design study was conducted on 11 healthy volunteers. Tiotropium or placebo was administered in two different testing sessions. Time domain parameters; mean R-R interval (mean-RR), the standard deviation of R-R interval (SDNN) and the root mean square of successive R-R interval differences (RMSSD) and power spectral analysis of HRV were assessed in the supine position, during handgrip exercise and controlled breathing before and after drug administration. Results: There were no statistically significant difference in baseline HRV parameters obtained before each drug administration (p >0.05). HRV parameters obtained after each drug administration were found not to be different during supine position, controlled breathing and handgrip exercise. Conclusion: Administration of single dose tiotropium did not effect cardiac autonomic modulations in healthy volunteers.
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Ünlü et al. (2006) studied this question.
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