What question did this study set out to answer?

To evaluate the diagnostic accuracy and clinical utility of the fibrinogen/fibrin fragment E antigen assay compared with venography in patients with suspected venous thrombosis.

February 1, 1982BloodOpen Access

The diagnostic value of the fibrinogen/fibrin fragment E antigen assay in clinically suspected deep vein thrombosis

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To evaluate the diagnostic accuracy and clinical utility of the fibrinogen/fibrin fragment E antigen assay compared with venography in patients with suspected venous thrombosis.
Assessed 272 patients presenting with clinically suspected venous thrombosis by comparing the fragment E antigen assay directly to venography.
Tested the assay in 130 medical and surgical control subjects without thrombosis as determined by leg scanning.
The fragment E antigen assay showed 99% sensitivity (elevated in 79 of 80 venogram-positive patients) and 84% specificity (normal in 161 of 192 venogram-negative patients).
A normal assay result achieved a negative predictive value of 99% (161 of 162 cases with normal results had no thrombosis), effectively excluding acute deep vein thrombosis in symptomatic patients.

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Implication

Diagnostic accuracy study demonstrates high sensitivity of fragment E assay in suspected deep vein thrombosis, indicating a normal result reliably rules out disease.

Cite This Study

Zielinsky et al. (1982) studied this question.

synapsesocial.com/papers/6a913b1f658779253246374c https://doi.org/10.1182/blood.v59.2.346.346

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Implication

Diagnostic accuracy study demonstrates high sensitivity of fragment E assay in suspected deep vein thrombosis, indicating a normal result reliably rules out disease.

The diagnostic value of the fibrinogen/fibrin fragment E antigen assay in clinically suspected deep vein thrombosis

Key Points

Discussion

Implication

Cite This Study

The diagnostic value of the fibrinogen/fibrin fragment E antigen assay in clinically suspected deep vein thrombosis

Key Points

Discussion

Implication

Cite This Study

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