Why the study?
Does second-hand smoke exposure induce cardiac fibrosis via the Fas death receptor apoptotic pathway in rats?
Population
Wistar rats
Comparison
Exposure to tobacco cigarette smoke at doses of… vs Unexposed control (implied)
Design
Preclinical
Follow-up
1 month
Authors
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Does not inform human second-hand smoke guidelines; leaves open Fas pathway role in cardiac fibrosis.
Does second-hand smoke exposure induce cardiac fibrosis via the Fas death receptor apoptotic pathway in rats?
Second-hand smoke induces cardiac fibrosis in rats via the Fas death-receptor-dependent apoptotic pathway rather than the mitochondria-dependent pathway.
Kuo et al. (2005) studied this question.
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