Sympathicolytic Agents Used to Separate Secretory and Vascular Effects of Sympathetic Stimulation in the Submaxillary Gland

Summary. The effect of some sympathicolytic agents on the secretory and vascular responses to sympathetic stimulation in the submaxillary gland of the cat has been investigated. With chlorpromazine it is possible to abolish the secretory effect, leaving the constriction intact. Regitin has a similar but far less selective effect. Priscol abolishes the constriction, sparing the secretion. Dihydroergotamine and Antistin both affect the secretion and the constriction to the same extent. The vasodilatation which is obtained on sympathetic stimulation is closely connected with the secretion and very likely due to metabolites with vasodilator action.