What question did this study set out to answer?

To review the biochemical mechanisms, transport systems, and metabolic interactions through which metal oxyanions and divalent metal cations induce cellular dysfunction and carcinogenesis.

August 1, 1981Environmental Health PerspectivesOpen Access

The role of metals in carcinogenesis: biochemistry and metabolism.

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KJK. W. JennetteDartmouth College

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Implication

Biochemical review uncovers mechanisms of toxic metal transport, macromolecular binding, and oxidative stress in human cells, highlighting pathways driving metal-induced carcinogenesis.

Key Points

To review the biochemical mechanisms, transport systems, and metabolic interactions through which metal oxyanions and divalent metal cations induce cellular dysfunction and carcinogenesis.
Examined cellular transport routes and intracellular sulfuryl/phosphoryl transfer reactions involving high oxidation state oxyanions (vanadium, chromium, molybdenum, arsenic, selenium).
Analyzed biological mimicry of physiological cations, macromolecular complexation, and free radical generation by toxic divalent metal ions.
Metal oxyanions cross cell membranes via physiological phosphate and sulfate transport pathways, forming hydrolytically unstable ester analogues and reacting with protein sulfhydryl groups.
Divalent cations (beryllium, cadmium, nickel, lead, mercury) mimic essential ions like magnesium and zinc, binding enzymes and nucleic acids to impair normal cellular function.
Redox-active metal metabolites stimulate the generation of reactive free radicals, causing widespread oxidative damage to critical intracellular molecules.

Cite This Study

K. W. Jennette (1981) studied this question.

synapsesocial.com/papers/6a913e74bd296d8bc511ffc2 https://doi.org/10.1289/ehp.8140233

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Implication

Biochemical review uncovers mechanisms of toxic metal transport, macromolecular binding, and oxidative stress in human cells, highlighting pathways driving metal-induced carcinogenesis.

The role of metals in carcinogenesis: biochemistry and metabolism.

Discussion

Member takes

Implication

Key Points

Cite This Study

The role of metals in carcinogenesis: biochemistry and metabolism.

Discussion

Member takes

Implication

Key Points

Cite This Study

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