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July 1, 1992American Review of Respiratory Disease

Role of Potassium Channels in Bronchodilator Responses in Human Airways

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Population

Human airways (smooth muscle)

Comparison

Potassium channel blockers added to… vs Absence of potassium channel blockers

Design

Preclinical

Authors

MMMotohiko MiuraTohoku UniversityMBMaria G. BelvisiLung InstituteCSC.D. StrettonLung Institute

Discussion

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Implication

Hypothesis-generating for ChTX-sensitive K+ channels in beta-agonist bronchodilation; human validation required before any clinical consideration.

Structured PICO

P
Population
Human airways (smooth muscle)
I
Intervention
Potassium channel blockers (charybdotoxin 10 or 100 nM, apamin 0.1 microM, BRL 31660 10 microM) added to bronchodilators (isoproterenol, theophylline, lemakalim)
C
Comparator
Absence of potassium channel blockers
O
Outcome
Relaxation concentration-response (bronchodilation)surrogate

Charybdotoxin-sensitive potassium channels are involved in bronchodilation induced by beta-agonists and theophylline in human airways.

Cite This Study

Miura et al. (1992) studied this question.

synapsesocial.com/papers/6a914121dc264a2e5a11fb45https://doi.org/10.1164/ajrccm/146.1.132
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The relaxant action of nicorandil in guinea‐pig isolated trachealis1986 · 48 citations
  2. 2Calcium‐activated potassium channels in canine airway smooth muscle.1986 · 159 citations
  3. 3A patch‐clamp study of K<sup>+</sup>‐channel activity in bovine isolated tracheal smooth muscle cells1991 · 47 citations
  4. 4Evaluation of the potassium channel activator cromakalim (BRL 34915) as a bronchodilator in the guinea‐pig: comparison with nifedipine1988 · 89 citations
  5. 5Cromakalim‐induced relaxation of guinea‐pig isolated trachealis: antagonism by glibenclamide and by phentolamine1989 · 72 citations