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Summary: A simple aliphatic modification demonstrated how to turn a water‐soluble biodegradable triblock copolymer synthesized from PEG, L‐lactide, and ε‐caprolactone into a thermoreversible polymer of which aqueous solution underwent a sol‐to‐gel phase transition upon a mild temperature rise. Thermogelling behavior of the aliphatically modified polymer was dependent on the degree of aliphatic modification and polymer concentration. When the polymer solutions were subcutaneously injected into rats, immediate depot formation has been observed. The polymeric gel depots have lasted for two weeks in vivo. This aliphatically modified thermogelling polymer can find applications in drug delivery. Aliphatically modified biodegradable triblock copolymer and its thermal gelation. magnified image Aliphatically modified biodegradable triblock copolymer and its thermal gelation.
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Jo et al. (2006) studied this question.
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