Some experimenters carry out their investigation in stages. They begin with an initial 2n-p fraction of resolution IV, in which the main effects are clean and the interactions are aliased in chains, Then, having analyzed the initial experiment, they plan further runs to isolate certain interactions by breaking the chains. In this paper a method called semifolding, for choosing the points in the second experiment, is presented.
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Peter W. M. John (2000) studied this question.
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