Three LD (MLC) Determinants. A Danish Population Study

During a search among offsprings of first cousin marriages three SD and LD homozygous individuals were found. They are supposed to define three alleles ‐j, lands‐ at the major MLC locus. In a sample of 101 unrelated and healthy adult Danes, the gene frequency was found to beP(j)= 0.078,P(l)= 0.1225 andP(s)= 0.1460. Each of these genes was found to be strongly associated with one or two SD genes ‐ most often at the FOUR series ‐ and the degree of gametic association was similar to that of the SD haplotypes, HL‐A1,8 and HL‐A3,7. The allelejshowed the strongest association with W5, whilesshowed association with HL‐A7 andlis associated with both HL‐A12 and W19. The reliability of the MLC typing was found to be sufficiently good forjandswhile it was not so good forl.The reproducibility in J typings is better than 98 %.