What question did this study set out to answer?

To evaluate the effectiveness and implementation potential of providing e-cigarettes as a harm reduction strategy for cancer outpatients who decline standard tobacco cessation interventions.

August 28, 2026Addiction Science & Clinical PracticeOpen Access

A novel harm reduction approach for oncology outpatients who smoke and refuse traditional tobacco treatment: a protocol for a type 1 hybrid effectiveness-implementation trial

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Authors

TSTracy T. SmithMedical University of South Carolina PBParis BedfordMedical University of South Carolina MCMatthew J. CarpenterMedical University of South Carolina

Discussion

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Implication

Randomized trial reports a harm reduction protocol using e-cigarettes in oncology outpatients refusing standard cessation, indicating an alternative strategy to lower carcinogen exposure.

Key Points

To evaluate the effectiveness and implementation potential of providing e-cigarettes as a harm reduction strategy for cancer outpatients who decline standard tobacco cessation interventions.
Adult oncology smokers at an NCI-designated cancer center refusing standard tobacco treatment are randomized to receive either a 13-week supply of e-cigarettes with a switching workbook or a quit-smoking workbook alone (Trial registration: NCT07039292).
Participants randomized to e-cigarettes establish a switch date within two weeks to transition exclusively to e-cigarettes.
Assessments are administered biweekly during product provision, with primary follow-up extending through 6 months.
The primary endpoint evaluates complete switching at 6 months, defined as biochemically verified 7-day point prevalence abstinence with expired breath carbon monoxide ≤ 5 ppm.
Secondary outcomes assess implementation barriers and facilitators, changes in biomarkers of cancer risk, and health-related quality of life.

Cite This Study

Smith et al. (2026) studied this question.

synapsesocial.com/papers/6a9145c5d15324a1df3a8ff1 https://doi.org/10.1186/s13722-026-00717-8

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August 28, 2026Addiction Science & Clinical PracticeOpen Access

A novel harm reduction approach for oncology outpatients who smoke and refuse traditional tobacco treatment: a protocol for a type 1 hybrid effectiveness-implementation trial

View Full Paper

Ask AI

Bookmark

Authors

TSTracy T. SmithMedical University of South Carolina PBParis BedfordMedical University of South Carolina MCMatthew J. CarpenterMedical University of South Carolina

Discussion

Member takes

Implication

Randomized trial reports a harm reduction protocol using e-cigarettes in oncology outpatients refusing standard cessation, indicating an alternative strategy to lower carcinogen exposure.

Key Points

To evaluate the effectiveness and implementation potential of providing e-cigarettes as a harm reduction strategy for cancer outpatients who decline standard tobacco cessation interventions.
Adult oncology smokers at an NCI-designated cancer center refusing standard tobacco treatment are randomized to receive either a 13-week supply of e-cigarettes with a switching workbook or a quit-smoking workbook alone (Trial registration: NCT07039292).
Participants randomized to e-cigarettes establish a switch date within two weeks to transition exclusively to e-cigarettes.
Assessments are administered biweekly during product provision, with primary follow-up extending through 6 months.
The primary endpoint evaluates complete switching at 6 months, defined as biochemically verified 7-day point prevalence abstinence with expired breath carbon monoxide ≤ 5 ppm.
Secondary outcomes assess implementation barriers and facilitators, changes in biomarkers of cancer risk, and health-related quality of life.

Cite This Study

Smith et al. (2026) studied this question.

synapsesocial.com/papers/6a9145c5d15324a1df3a8ff1 https://doi.org/10.1186/s13722-026-00717-8

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