Determination of Potassium in Infusion Solutions Using Cation Exchange Separation and Radioluminography

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Potassium concentration in infusion solutions can be accurately quantified with 95-105% accuracy at 40 and 60 mEq/L using beta-ray measurement from the natural radionuclide 40K combined with cation exchange separation and radioluminography. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Shuhei Sakai; Hideki Fujino

doi:10.3769/radioisotopes.750302

August 25, 2026RADIOISOTOPESOpen Access

Determination of Potassium in Infusion Solutions Using Cation Exchange Separation and Radioluminography

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Key Points

To develop and evaluate an analytical method for measuring potassium concentrations in intravenous infusion solutions by detecting beta emissions from naturally occurring potassium-40.
Potassium ions from 40 mL infusion solution samples were adsorbed onto 3 g of cation exchange resin to eliminate coexisting additives such as glucose.
Radioactivity from potassium-40 was quantified using radioluminography across various infusion formulations.
The cation exchange procedure successfully separated potassium ions while removing interfering co-solutes.
Radioluminographic quantification achieved an accuracy within 95% to 105% of target values for infusion preparations containing 40 and 60 mEq/L of potassium.

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Implication

Laboratory evaluation demonstrates accurate potassium quantification in medical infusion solutions, indicating potential utility for preventing lethal medication errors.

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Sakai et al. (2026) studied this question.

synapsesocial.com/papers/6a9145c5d15324a1df3a9094 https://doi.org/10.3769/radioisotopes.750302

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Determination of Potassium in Infusion Solutions Using Cation Exchange Separation and Radioluminography

Key Points

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Implication

Abstract

Discussion

Cite This Study

Determination of Potassium in Infusion Solutions Using Cation Exchange Separation and Radioluminography

Key Points

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Implication

Abstract

Discussion

Cite This Study

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