What does this research mean for the field?

Arthrogenic muscle inhibition following acute anterior cruciate ligament (ACL) rupture is associated with altered cerebellar connectivity and increased subcortical activation, indicating a supraspinal central neural contribution to the impairment. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To investigate sensorimotor brain network connectivity changes associated with arthrogenic muscle inhibition using resting-state and task-based functional magnetic resonance imaging in males with acute ACL tears.

August 28, 2026Sports Medicine - OpenOpen Access

Cerebellar and Subcortical Connectivity Associated with Arthrogenic Muscle Inhibition After Acute ACL Rupture in Males: A Clinical and fMRI Study

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Authors

BSBertrand Sonnery-CottetCentre Orthopédique Santy PPPatrice PéranUniversité Toulouse III - Paul Sabatier DGDustin R. GroomsOhio University

Discussion

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Implication

Randomized trial reveals altered cerebellar connectivity in acute ACL rupture, highlighting central brain mechanisms in arthrogenic muscle inhibition.

Key Points

To investigate sensorimotor brain network connectivity changes associated with arthrogenic muscle inhibition using resting-state and task-based functional magnetic resonance imaging in males with acute ACL tears.
Registered trial (NCT03950024) evaluating 40 male patients (mean age 24.1 ± 2.9 years) with acute anterior cruciate ligament rupture at an average of 22.7 ± 7 days post-injury.
Participants were clinically classified into arthrogenic muscle inhibition (n = 20) and non-inhibition (n = 20) groups using the SANTI classification system.
All patients underwent resting-state and motor imagery task-based functional magnetic resonance imaging (fMRI) to evaluate sensorimotor network connectivity.
Patients with arthrogenic muscle inhibition presented clinically with more frequent knee extension deficits and qualitative vastus medialis obliquus muscle inhibition.
Resting-state fMRI demonstrated significantly greater functional connectivity of the right cerebellar Crus 1 with sensory and cognitive cortical brain regions in the inhibition group.
Exploratory task-based analyses showed greater activation in the right caudate nucleus and right thalamus during motor imagery of the injured limb in patients with muscle inhibition.

Cite This Study

Sonnery-Cottet et al. (2026) studied this question.

synapsesocial.com/papers/6a9145ead15324a1df3a91a0 https://doi.org/10.1186/s40798-026-01096-9

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Implication

Randomized trial reveals altered cerebellar connectivity in acute ACL rupture, highlighting central brain mechanisms in arthrogenic muscle inhibition.

Cerebellar and Subcortical Connectivity Associated with Arthrogenic Muscle Inhibition After Acute ACL Rupture in Males: A Clinical and fMRI Study

Discussion

Member takes

Implication

Key Points

Cite This Study

Cerebellar and Subcortical Connectivity Associated with Arthrogenic Muscle Inhibition After Acute ACL Rupture in Males: A Clinical and fMRI Study

Discussion

Member takes

Implication

Key Points

Cite This Study

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