Formation of Lanthanide Luminescent Aggregates With RNA Using Tripodal Europium [Eu(III)] BTA Self‐Assembled Complexes

Q: What does this research mean for the field?

Terpyridine-appended β-peptide and its tripodal BTA derivative form Eu(III) self-assembled materials that exhibit significantly enhanced luminescence upon binding to RNA due to changes in the water coordination environment. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Tómas A. Gudmundsson; Changzhuang Bai; Grace E. Maynard; Pall Thordarson; Thorfinnur Gunnlaugsson

doi:10.1002/chem.71601

August 25, 2026Chemistry - A European JournalOpen Access

Formation of Lanthanide Luminescent Aggregates With RNA Using Tripodal Europium [Eu(III)] BTA Self‐Assembled Complexes

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Key Points

To evaluate the self-assembly and luminescence response of tripodal europium(III) benzene-1,3,5-tricarboxamide complexes upon interaction with RNA.
Synthesized a terpyridine-appended β-peptide and its tripodal benzene-1,3,5-tricarboxamide (BTA) derivative to generate self-assembled Eu(III) complexes.
Assayed luminescence emission and aggregate formation upon introduction of torula yeast RNA in buffered pH 7 HEPES solution using optical imaging platforms.
Demonstrated significant enhancement of Eu(III) metal ion-centered emission upon binding torula yeast RNA.
Confirmed the formation of luminescent aggregates resulting from altered water coordination around the Eu(III) center following coordination to the RNA phosphate diester backbone.

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Implication

In vitro study reveals enhanced Europium(III) emission upon binding torula yeast RNA, indicating aggregate formation and water displacement.

Abstract

A terpyridine-appended β-peptide and its tripodal benzene-1,3,5-tricarboxamide (BTA) derivative formed luminescent Eu(III) self-assembled materials, showing significant enhanced metal ion centered emission upon torula yeast RNA binding in buffered pH 7 HEPES solution due to the formation of luminescent aggregates as probed by using imaging platforms; attributed to changes in the water coordination environment of the Eu(III) center upon binding to the phosphate di-ester backbone of the RNA.

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Gudmundsson et al. (2026) studied this question.

synapsesocial.com/papers/6a914613d15324a1df3a958a https://doi.org/10.1002/chem.71601

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Formation of Lanthanide Luminescent Aggregates With RNA Using Tripodal Europium [Eu(III)] BTA Self‐Assembled Complexes

Key Points

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Abstract

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Cite This Study

Formation of Lanthanide Luminescent Aggregates With RNA Using Tripodal Europium [Eu(III)] BTA Self‐Assembled Complexes

Key Points

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Implication

Abstract

Discussion

Cite This Study

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