What does this research mean for the field?

There is currently a lack of controlled comparative studies to establish evidence-based differential diagnostic criteria between molar incisor hypomineralisation (MIH), hypomineralised second primary molars (HSPM), and other developmental enamel defects. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To systematically map literature detailing clinical, radiological, histological, and patient-reported features for the differential diagnosis of molar incisor hypomineralisation (MIH) and hypomineralised second primary molars (HSPM), and to identify key research gaps.

August 28, 2026European Archives of Paediatric DentistryOpen Access

Differential diagnosis of molar incisor hypomineralisation and hypomineralised second primary molars: a scoping review

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Authors

EGE. GarotUniversité de Bordeaux LLL. Bandeira LopesEscola Superior de Saúde Egas Moniz MEM. ElfrinkInfor (Netherlands)

Discussion

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Implication

Scoping review finds an absence of controlled comparative studies distinguishing molar incisor hypomineralisation from other enamel defects, highlighting a critical gap in diagnostic criteria.

Key Points

To systematically map literature detailing clinical, radiological, histological, and patient-reported features for the differential diagnosis of molar incisor hypomineralisation (MIH) and hypomineralised second primary molars (HSPM), and to identify key research gaps.
Searched PubMed/MEDLINE, EMBASE, Cochrane Library, and Scopus for English-language human studies published between 1985 and 2025 (OSF registration: 10.17605/OSF.IO/P9UKD).
Screened retrieved publications and extracted data independently using two reviewers.
Synthesized 23 included reports, predominantly consisting of case series (39.1%) and case reports (17.4%), with 50.0% of studies evaluating fewer than 10 subjects.
Identified amelogenesis imperfecta in 65.2% of reports alongside dental fluorosis and white spot lesions, but noted zero controlled studies directly comparing MIH or HSPM against other enamel defects.

Cite This Study

Garot et al. (2026) studied this question.

synapsesocial.com/papers/6a914642d15324a1df3a9ccf https://doi.org/10.1007/s40368-026-01207-w

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Implication

Scoping review finds an absence of controlled comparative studies distinguishing molar incisor hypomineralisation from other enamel defects, highlighting a critical gap in diagnostic criteria.

Differential diagnosis of molar incisor hypomineralisation and hypomineralised second primary molars: a scoping review

Discussion

Member takes

Implication

Key Points

Cite This Study

Differential diagnosis of molar incisor hypomineralisation and hypomineralised second primary molars: a scoping review

Discussion

Member takes

Implication

Key Points

Cite This Study

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