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August 28, 2026Behavioral SciencesOpen Access

Effectiveness of School-Based Integrated Mental Health and Substance Use Prevention Programs for Adolescents: A Systematic Review and Meta-Analysis

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Authors

JSJihye ShinCatholic University of PusanKHKyung‐Young HongEulji University

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Implication

Systematic review reveals integrated school prevention programs curb adolescent alcohol misuse, indicating the value of combining mental wellness and substance education.

Key Points

  • To evaluate the effectiveness of integrated school-based mental health and substance use prevention programs on adolescent substance misuse and psychosocial outcomes.
  • Searched 12 electronic databases (January 2016 to April 2026) for randomized controlled trials (RCTs) and cluster RCTs evaluating integrated school-based prevention programs for adolescents.
  • Conducted random-effects meta-analyses using pooled odds ratios (ORs) and 95% confidence intervals (CIs) for substance-use outcomes, alongside a narrative synthesis for mental health and psychosocial endpoints.
  • Identified 16 reports representing 10 independent trials, including 5 independent trial comparisons in the primary quantitative meta-analysis.
  • Integrated prevention programs significantly lowered alcohol-related behaviors compared to control conditions (OR = 0.56, 95% CI = 0.37–0.86, p = 0.008).
  • Interventions demonstrated marked protective effects against binge drinking (OR = 0.32, 95% CI = 0.16–0.64, p = 0.001).
  • Narrative synthesis indicated potential short-term gains in psychosocial and mental health metrics, though high heterogeneity prevented quantitative pooling and benefits were inconsistently sustained over follow-up.

Cite This Study

Shin et al. (2026) studied this question.

synapsesocial.com/papers/6a91467bd15324a1df3aa246https://doi.org/10.3390/bs16091498
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