What does this research mean for the field?

Cytochrome P450 and glutathione S-transferase (GST) enzymes, specifically those encoded by the PfGSTU6 and PfGSTL1 genes, confer non-target-site resistance to the herbicide mesosulfuron-methyl in the weed Polypogon fugax through enhanced metabolism. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the resistance levels, cross-resistance profiles, and metabolic mechanisms conferring mesosulfuron-methyl resistance in Polypogon fugax.

August 28, 2026Pest Management ScienceOpen Access

Glutathione S ‐transferase genes Pf GSTU6 and Pf GSTL1 involved in mesosulfuron‐methyl resistance in Polypogon fugax

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To evaluate the resistance levels, cross-resistance profiles, and metabolic mechanisms conferring mesosulfuron-methyl resistance in Polypogon fugax.
Conducted whole-plant dose-response assays, cross-resistance tests against ACCase and PDS inhibitors, and conserved ALS gene sequencing in field-collected SD-4 and JS-13 populations.
Measured herbicide metabolism and enzyme activity changes using the P450 inhibitor malathion and the GST inhibitor NBD-Cl.
Identified upregulated candidate genes through transcriptomic and qRT-PCR analyses, confirming functional resistance via Escherichia coli, transgenic rice callus, and molecular docking.
Populations SD-4 and JS-13 demonstrated 15.9-fold and 16.4-fold resistance to mesosulfuron-methyl and cross-resistance to clodinafop-propargyl, fenoxaprop-P-ethyl, quizalofop-p-ethyl, and diflufenican without target-site mutations in the ALS gene.
Pre-treatment with malathion or NBD-Cl restored herbicide sensitivity and decreased accelerated mesosulfuron-methyl metabolism in resistant plants.
Overexpression of PfGSTU6 and PfGSTL1 significantly increased mesosulfuron-methyl tolerance in both Escherichia coli and rice callus, supported by strong binding affinities in molecular docking.

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Implication

Laboratory study reveals metabolic mesosulfuron-methyl resistance in Polypogon fugax mediated by glutathione S-transferases, highlighting cross-resistance risks in crop weed management.

Cite This Study

Zou et al. (2026) studied this question.

synapsesocial.com/papers/6a91468ad15324a1df3aa3ea https://doi.org/10.1002/ps.71227

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Implication

Laboratory study reveals metabolic mesosulfuron-methyl resistance in Polypogon fugax mediated by glutathione S-transferases, highlighting cross-resistance risks in crop weed management.

Glutathione S ‐transferase genes Pf GSTU6 and Pf GSTL1 involved in mesosulfuron‐methyl resistance in Polypogon fugax

Key Points

Discussion

Implication

Cite This Study

Glutathione S ‐transferase genes Pf GSTU6 and Pf GSTL1 involved in mesosulfuron‐methyl resistance in Polypogon fugax

Key Points

Discussion

Implication

Cite This Study

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