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A new concept for fabricating nanocarriers carrying free DNA for gene delivery to overcome the intracellular dissociation barrier of cationic polymer/DNA complexes is presented. Free DNA plasmids (shown in green) are encapsulated in a nanocapsule core, which is protected by a hydrophobic membrane (purple) with a poly(ethylene glycol) outer layer (blue). The nanocapsules can release free DNA into the cells and have high in vitro and in vivo transfection efficiency.
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Xu et al. (2008) studied this question.
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