Why the study?
Does tumor resection employing circulatory arrest improve survival in patients with cavo-atrial renal cell carcinoma?
Does tumor resection employing circulatory arrest improve survival in patients with cavo-atrial renal cell carcinoma?
Circulatory arrest appears to be a relatively safe technique for removing renal carcinoma with cavo-atrial extension, with outcomes primarily limited by preoperative metastases and myocardial dysfunction.
Mortality driven by cardiac compromise and metastases in this small series; leaves open survival benefit of circulatory arrest in cavo-atrial RCC.
From 1990 to 1995, 12 patients with cavo-atrial renal cell carcinoma underwent resection of the tumor. Circulatory arrest was employed in 11/12 cases. The neoplasm extended to the inferior vena cava in two patients and to the intrahepatic veins or right atrium in five cases. Two severely cardiac compromised patients died perioperatively. Of five patients who showed preoperative suspicion of isolated metastases, 3 patients died postoperatively because of relapsing disease after a mean period of 10.8 months. Five patients are alive and doing well after a mean follow-up of 14.8 months. In our experience myocardial dysfunction determined poor immediate survival. Mid-term survival was influenced by preoperative metastases and lymph-node involvement, but not by intracaval extension. Circulatory arrest appears to be a relatively safe technique to remove renal carcinoma with cavo-atrial extension and should be indicated whenever there are no metastases.
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Donatelli et al. (1998) studied this question.
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