May 2, 2013Circulation Cardiovascular Imaging
Percutaneous Mitral Valve Repair in the Initial EVEREST Cohort
Why the study?
Does percutaneous reduction of mitral regurgitation with the MitraClip device induce reverse left ventricular remodeling at 12 months in patients with 3+ and 4+ MR?
Population
64 patients with 3+ and 4+ mitral regurgitation who achieved acute procedural success after treatment with…
Comparison
Percutaneous reduction of mitral regurgitation… vs Patients with normal baseline left ventricular…
Design
Cohort
Follow-up
12 months
Authors
Discussion
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Member takes
Implication
Supports reverse remodeling with MitraClip in LV dysfunction but EF decline in normal LV; hypothesis-generating and requires prospective validation.
Structured PICO
Does percutaneous reduction of mitral regurgitation with the MitraClip device induce reverse left ventricular remodeling at 12 months in patients with 3+ and 4+ MR?
P
Population
64 patients with 3+ and 4+ mitral regurgitation (MR) who achieved acute procedural success after treatment with the MitraClip device, of which 49 had moderate or less MR at 12-month follow-up.
I
Intervention
Percutaneous reduction of mitral regurgitation with the MitraClip device
C
Comparator
Patients with normal baseline left ventricular (LV) function (comparison between groups with and without pre-existing LV dysfunction)
O
Outcome
Extent of reverse remodeling (changes in LV wall stress, LV end-diastolic volume, LV end-systolic volume, and LV ejection fraction) at 12 monthssurrogate
Percutaneous mitral valve repair with the MitraClip device promotes favorable reverse left ventricular remodeling and improves ejection fraction in patients with pre-existing LV dysfunction.
Cite This Study
Foster et al. (2013) studied this question.