Key result
Dilated cardiomyopathy in giant breed dogs was associated with substantial differences in left ventricular size and systolic indices compared to healthy controls (P=0.0001).
Why the study?
Does M-mode echocardiography differentiate between healthy giant breed dogs and those with asymptomatic or symptomatic dilated cardiomyopathy?
Observational (n=81)
Does M-mode echocardiography differentiate between healthy giant breed dogs and those with asymptomatic or symptomatic dilated cardiomyopathy?
p-value: p=0.0001
M-mode echocardiography provides reference values and identifies significant structural and functional differences in giant breed dogs with varying stages of dilated cardiomyopathy.
M-mode echocardiography may differentiate giant-breed DCM; hypothesis-generating and requires prospective validation before clinical adoption.
M-mode echocardiograms were recorded from 62 giant breed dogs without historical, clinical, electrocardiographic and roentgenologic signs of heart disease, from six dogs with asymptomatic dilated cardiomyopathy (DCM, NYHA class I), and 13 dogs with symptomatic DCM (NYHA class III-IV). There was a general trend that several echocardiographic parameters were significantly in control Great Danes as compared to Newfoundlands and Irish Wolfhounds. There were substantial differences in left ventricular size both in systole and diastole and in systolic indices of the left ventricle between the control group, the asymptomatic dogs and symptomatic dogs with DCM (P = 0.0001). There was also a significant decreased in the interventricular septum thickness (P = 0.0001) and left ventricular free wall thickness in systole (P = 0.002) and diastole (P = 0.005) between the three groups. Furthermore, the left atrial/aortic ratio was significantly different between the three groups (P = 0.0001). It was concluded that this study established echocardiographic reference values in giant breed dogs which may be useful in the study of heart diseases in giant breed dogs.
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Koch et al. (1996) conducted an observational in Dilated cardiomyopathy (n=81). Dilated cardiomyopathy vs. Healthy control giant breed dogs was evaluated on Left ventricular size and systolic indices (p=0.0001). Dilated cardiomyopathy in giant breed dogs was associated with substantial differences in left ventricular size and systolic indices compared to healthy controls (P=0.0001).