Deposition of lipofuscin and elastic fibers in the skin of the senescence-accelerated mouse.

In an animal model of aging, the accelerated senescence-prone (SAM-P/1) mouse, we found the deposition of lipofuscin and elastic fibers in the skin of 12-month-old animals of this strain. The deposition was most remarkable in the dorsal neck and head skin. Taking into account our previous data that the lipid peroxide level in the dorsal neck and head skin significantly increases prior to the appearance of the age-related signs in these areas of the skin, we propose that the increased lipid peroxides would cause the deposition of not only lipofuscin but also elastic fibers in the skin of SAM-P/1 mouse.