Key result
Multimodality stress testing combining 3D echocardiography and SPECT correctly identified 13 of 13 diseased arteries, compared with 11 by SPECT and 6 by echocardiography alone.
Why the study?
Does a multimodality stress test combining real-time 3D echocardiography and SPECT improve the detection of diseased arteries compared to either modality alone in patients referred for CAD evaluation?
Observational (n=20)
Does a multimodality stress test combining real-time 3D echocardiography and SPECT improve the detection of diseased arteries compared to either modality alone in patients referred for CAD evaluation?
Combining real-time 3D echocardiography and SPECT into a fused multimodality stress test is feasible and may improve the detection of coronary artery disease compared to either modality alone.
Answers are grounded in this paper and cite their sources.
May support fused 3D echo-SPECT for CAD detection; hypothesis-generating and should not yet change practice.
UNLABELLED: Early experience is described in implementing a new multimodality stress test for accurate correlation of complementary functional and perfusion information from real-time 3-dimensional (3D) echocardiography and SPECT, respectively. The proposed new multimodality stress test has the potential for simultaneously improving sensitivity and specificity in the detection of early coronary artery disease (CAD). METHODS: Pre- and poststress real-time 3D echocardiography and SPECT images were acquired in 20 patients referred for CAD evaluation and processed using previously developed algorithms for automatic fusion and quantitative analysis of myocardial function and perfusion. All cases of CAD were diagnosed by reviewing quantitatively analyzed fused images, using newly developed software. RESULTS: Real-time 3D echocardiography, SPECT, advance processing, and image review were successfully performed in all 20 patients. Compared with the angiographic findings in 12 patients, diagnosis based on fused images correctly identified 13 of 13 diseased arteries, compared with 11 of 13 identified by SPECT and 6 of 13 identified by echocardiography-based analysis. CONCLUSION: The results suggest the feasibility and potential effectiveness of novel multimodality stress testing.
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Walimbe et al. (2009) conducted an observational in Coronary artery disease (n=20). Multimodality stress testing combining real-time 3D echocardiography and myocardial perfusion SPECT vs. SPECT alone and echocardiography alone was evaluated on Identification of diseased arteries compared with angiographic findings. Multimodality stress testing combining 3D echocardiography and SPECT correctly identified 13 of 13 diseased arteries, compared with 11 by SPECT and 6 by echocardiography alone.
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