The neurogenic component, involving interactions between the renin-angiotensin and sympathetic nervous systems, plays a critical role in the pathophysiology of chronic hypertension.
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May inform neurogenic hypertension therapies; leaves open translation from animal models to clinical practice.
The neurogenic component appears to be an integral part of the “mosaic” of factors underlying chronic hypertension. Studies in many animal models have shown a critical interaction between the renin-angiotensin and the sympathetic nervous systems and have demonstrated the presence of an angiotensin-sensitive neural structure in the brain. The implications of these findings for human essential hypertension are discussed.
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Ferrario et al. (1974) studied this question.
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