Genetic testing in antiplatelet therapy – not effective for perioperative bleeding

Q: What is the clinical evidence from this study?

Study design: Editorial. Population: Ischemic heart disease undergoing coronary angiography or PCI (n=404). Intervention: Single nucleotide polymorphisms of platelet receptors (GPIa, GPVI, P2Y12) vs. Patients without the specific SNPs. Primary outcome: Periprocedural bleeding complications within 30 days.

Wiktor Kuliczkowski

doi:10.5114/aic.2017.70184

January 1, 2017Advances in Interventional CardiologyOpen Access

Genetic testing in antiplatelet therapy – not effective for perioperative bleeding

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Why the study?

Does genetic testing of platelet receptors predict periprocedural bleeding in patients undergoing coronary angiography or PCI?

Structured PICO

Does genetic testing of platelet receptors predict periprocedural bleeding in patients undergoing coronary angiography or PCI?

P

Population

404 patients with ischemic heart disease undergoing coronary angiography or PCI, comprising 73 with non-severe bleeding events within 30 days and 331 controls without bleeding.

E

Exposure

Genetic analysis of single nucleotide polymorphisms (SNPs) of hemostatic platelet receptors (GPIa, GPVI, P2Y12)

O

Outcome

Periprocedural bleeding complications during 30 days after the proceduresafety

Limitations

Exclusion of patients with the most severe types of bleeding (intracranial or fatal) due to inability to obtain informed consent.
Small number of non-access site bleeding events makes it challenging to obtain meaningful results regarding platelet-related bleeding.
Lack of prospective randomized data to guide treatment changes based on genetic profiles.
Small number of individuals included in genetic studies
Exclusion of patients with the most severe types of bleeding (intracranial or fatal)

Implication

Genetic testing for platelet receptor polymorphisms does not effectively predict periprocedural bleeding in PCI, which is more strongly driven by clinical factors.

Abstract

ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Kuliczkowski W. Genetic testing in antiplatelet therapy – not effective for perioperative bleeding. Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej. 2017;13(3):187-188. doi:10.5114/aic.2017.70184. APA Kuliczkowski, W. (2017). Genetic testing in antiplatelet therapy – not effective for perioperative bleeding. Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej, 13(3), 187-188. https://doi.org/10.5114/aic.2017.70184 Chicago Kuliczkowski, Wiktor. 2017. "Genetic testing in antiplatelet therapy – not effective for perioperative bleeding". Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej 13 (3): 187-188. doi:10.5114/aic.2017.70184. Harvard Kuliczkowski, W. (2017). Genetic testing in antiplatelet therapy – not effective for perioperative bleeding. Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej, 13(3), pp.187-188. https://doi.org/10.5114/aic.2017.70184 MLA Kuliczkowski, Wiktor. "Genetic testing in antiplatelet therapy – not effective for perioperative bleeding." Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej, vol. 13, no. 3, 2017, pp. 187-188. doi:10.5114/aic.2017.70184. Vancouver Kuliczkowski W. Genetic testing in antiplatelet therapy – not effective for perioperative bleeding. Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej. 2017;13(3):187-188. doi:10.5114/aic.2017.70184.

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Cite This Study

Wiktor Kuliczkowski (2017) conducted an editorial in Ischemic heart disease undergoing coronary angiography or PCI (n=404). Single nucleotide polymorphisms of platelet receptors (GPIa, GPVI, P2Y12) vs. Patients without the specific SNPs was evaluated on Periprocedural bleeding complications within 30 days.

synapsesocial.com/papers/6a9152f54680f0562fab4e8a https://doi.org/10.5114/aic.2017.70184

View Full Paper

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Genetic testing in antiplatelet therapy – not effective for perioperative bleeding

Structured PICO

Limitations

Implication

Abstract

Discussion

Cite This Study

Genetic testing in antiplatelet therapy – not effective for perioperative bleeding

Structured PICO

Limitations

Implication

Abstract

Discussion

Cite This Study

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