Divergence in postoperative platelet aggregation during antiplatelet monotherapy with aspirin in the early postoperative period following coronary artery bypass grafting: initial findings

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Chronic coronary syndrome undergoing CABG (n=40). Intervention: Aspirin vs. Aspirin 150 mg daily. Primary outcome: Arachidonic acid (AA)-induced platelet aggregation on postoperative days 5-7 (p=0.02).

Anna Kędziora; Magdalena Kopytek; Justyna Totoń‐Żurańska; Piotr Śliwiński; Agnieszka Branicka; Radosław Litwinowicz; Jacek Piątek; Bogusław Kapelak

doi:10.5114/aic.2026.160052

January 1, 2026Advances in Interventional CardiologyOpen Access

Divergence in postoperative platelet aggregation during antiplatelet monotherapy with aspirin in the early postoperative period following coronary artery bypass grafting: initial findings

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Key result

Post-CABG aspirin 75 mg is linked to ~12-fold higher AA-induced platelet aggregation versus 150 mg.

P=0.02
n=40

Figures

Why the study?

Does aspirin 150 mg daily compared to 75 mg daily improve early postoperative platelet inhibition in patients undergoing CABG?

Study Design

Type

Observational (n=40)

Multicenter

No

Structured PICO

Does aspirin 150 mg daily compared to 75 mg daily improve early postoperative platelet inhibition in patients undergoing CABG?

P

Population

40 patients who underwent on-pump coronary artery bypass grafting (CABG) for chronic coronary syndrome, median age 60.5, 88% male, single-center (Poland). Excluded: preoperative P2Y12 inhibitors or GP IIb/IIIa antiplatelet therapy, and requirement for perioperative platelet transfusions.

I

Intervention

Aspirin 150 mg oral daily, resumed within the first 24 hours postoperatively.

C

Comparator

Aspirin 75 mg oral daily, resumed within the first 24 hours postoperatively (dose determined by physician's decision).

O

Outcome

Arachidonic acid (AA)-induced platelet aggregation on postoperative days 5-7.surrogate

Main Result

Absolute Event Rate: 37% vs 3%

p-value: p=0.02

Early postoperative aspirin at 150 mg daily provides more consistent and potent platelet inhibition compared to 75 mg daily following CABG, highlighting significant interindividual variability with low-dose aspirin.

Limitations

Small sample size
Exploratory observational study without clinical outcomes
Non-randomized treatment allocation based on physician's decision
Did not assess clinical outcomes
Observational design based solely on laboratory data

Implication

Should not prompt aspirin dose changes post-CABG; leaves open whether 150 mg improves outcomes versus 75 mg.

Abstract

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Discussion

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Cite This Study

Kędziora et al. (2026) conducted an observational in Chronic coronary syndrome undergoing CABG (n=40). Aspirin vs. Aspirin 150 mg daily was evaluated on Arachidonic acid (AA)-induced platelet aggregation on postoperative days 5-7 (p=0.02). In patients undergoing CABG, postoperative aspirin at 75 mg daily resulted in significantly higher median AA-induced platelet aggregation compared to 150 mg daily (37% vs. 3%, p=0.02) on days 5-7.

synapsesocial.com/papers/6a025e8a93868c48f3093dc2 https://doi.org/10.5114/aic.2026.160052

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Divergence in postoperative platelet aggregation during antiplatelet monotherapy with aspirin in the early postoperative period following coronary artery bypass grafting: initial findings

Figures

Study Design

Structured PICO

Main Result

Limitations

Implication

Abstract

Discussion

Cite This Study

Divergence in postoperative platelet aggregation during antiplatelet monotherapy with aspirin in the early postoperative period following coronary artery bypass grafting: initial findings

Figures

Study Design

Structured PICO

Main Result

Limitations

Implication

Abstract

Discussion

Cite This Study

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