Synthesis of Azepine Derivatives by Silver‐Catalyzed [5+2] Cycloaddition of γ‐Amino Ketones with Alkynes

Silver forges the ring: A new and practical silver-catalyzed [5+2] cycloaddition method has been developed for the synthesis of azepines through the formation of four new chemical bonds between a γ-amino ketone and an alkyne in one step. This method provides a new hetero-[5+2] cycloaddition strategy for the construction of seven-membered ring systems.