Why the study?
Do selective COX-2 inhibitors prevent the protective effect of a mild irritant in the rat stomach?
Population
Rat stomach model
Comparison
Selective COX-2 inhibitors and non-selective COX… vs Mild irritant alone or other protective agents
Design
Preclinical
Authors
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Blocks ethanol gastroprotection in rats; leaves open constitutive COX-2 role in human gastric homeostasis.
Do selective COX-2 inhibitors prevent the protective effect of a mild irritant in the rat stomach?
Selective COX-2 inhibitors prevent the protection conferred by a mild irritant in the rat stomach, suggesting a role for constitutive COX-2 in gastric homeostasis.
Gretzer et al. (1998) studied this question.
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