Key result
Prolonged initial prothrombin time (≥ 14 seconds) was associated with a significantly higher risk of long-term all-cause mortality (HR 2.648) compared to low prothrombin time in patients with acute coronary syndrome undergoing PCI.
Why the study?
Does prolonged initial prothrombin time predict long-term all-cause mortality in ACS patients undergoing PCI not on anticoagulant therapy?
Cohort (n=1,100)
No
Does prolonged initial prothrombin time predict long-term all-cause mortality in ACS patients undergoing PCI not on anticoagulant therapy?
Answers are grounded in this paper and cite their sources.
Prolonged initial prothrombin time in the absence of anticoagulant therapy is an independent predictor of long-term all-cause mortality in patients with ACS undergoing PCI.
There are some studies regarding the prognostic value of coagulation abnormalities both in heart failure and acute pulmonary embolism patients. However, it is unclear whether prothrombin time (PT) at presentation will be associated with long-term mortality in acute coronary syndrome (ACS) patients not on anticoagulant therapy. Thus, we investigated the prognostic role of initial PT in such patients.
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Kırış et al. (2018) conducted a cohort in Acute Coronary Syndrome (ACS) (n=1,100). High prothrombin time (PT ≥ 14 sec) vs. Low prothrombin time (PT ≤ 12.5 sec) was evaluated on All-cause death (HR 2.648, 95% CI 1.590-4.410, p=< 0.001). Prolonged initial prothrombin time (≥ 14 seconds) was associated with a significantly higher risk of long-term all-cause mortality (HR 2.648) compared to low prothrombin time in patients with acute coronary syndrome undergoing PCI.
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